About the project that will be funded thanks to Venite Cantemus event
Schizophrenia is a serious disease that affects nearly 1% of the world's population. Schizophrenia is
characterized by hallucinations and delusions, social withdrawal and cognitive impairment. Recent studies have shown that genes encoding key components of the immune system are strongly associated with schizophrenia. In particular, genes conferring high expression of complement C4, a protein involved in the defense against pathogens, are among the strongest risk factors for schizophrenia. During her thesis, Mélanie Druart has developed new animal model of C4 overexpression in the brain. With this model, that reproduces several alterations of the schizophrenic brain, she wants to understand the C4 role in the brain defects associated with schizophrenia.